Call for abstract


Modeling the Mammalian Microbiota Host Superorganism, Current Tools and Challenges
Paris, October 15-16, 2018

Monday, October 15, 2018
08:00 am-09:00 am
09:00 am-09:15 am
Keynote lecture
09:15 am-10:00 am
09:15 am

Keynote lecture

A. Macpherson
University Bern, Bern, Switzerland 
Coffee break
10:00 am-10:30 am
Modelling the microbiota
10:30 am-12:40 pm
Chair: Eberl Gerard, Paris
10:30 am

Applying Koch´s Postulates to beneficial members of the microbiota

B. Stecher
Ludwig-Maximillians Uni., Germany 
11:00 am

Investigating the intestinal barrier : from mouse models to human monogenic pathology

N. Cerf-Bensussan
INSERM, France 
11:30 am

The contribution of metabolomics for studying the microbiota host interaction : challenges and opportunities

C. Junot
CEA, France 
12:00 pm

Dietary modulation regulates pathogen-induced colitis via mucus-degrading gut microbes

M. Wolter1, N. Pudlo2, M. Ollert3, E. Martens2, M. Desai*1-3
1Eco-Immunology and Microbiome Group, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg 2Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States 3Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark 
12:15 pm

Using transkingdom networks as a tool to uncover host-microbiota interactions

A. Morgun, N. Shulzhenko*
Oregon State University, Corvallis, United States 
12:30 pm

Metabolome meets Microbiome

C. Malpica
CEO, MLP Vision Biotech S.L. 
12:40 pm-02:00 pm
Animal models to study the microbiota
02:00 pm-04:30 pm
Chair: Milon Geneviève, Paris
02:00 pm

Host-Microbiota Mutualism upon Chronic Undernutrition: Lessons from gnotobiotic animal models

F. Leulier
Institute de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, UMR5242 CNRS, UCBL1, France 
02:30 pm

The zebrafish, an alternative model to decipher microbiota-mediated protection against oral pathogens

J. Levraud*1, F. Stressman2, J. Bernal-Bayard2, P. Hernandez-Cerda1, D. Perez Pasqual2, B. Audrain2, P. Strzelecka3, E. Athanasiadis3, E. Duchaud4, A. Cvejic3, J.M. Ghigo2
1Unité Macrophages et Développement de l’Immunité, Institut Pasteur, Paris, France 2Unité de Génétique des Biofilms, Institut Pasteur, Paris, France 3Wellcome Trust Sanger Institute, Cambridge, United Kingdom 4Virologie et Immunologie Moléculaire, INRA, Jouy-En-Josas, France 
03:00 pm

From mice to pigs: exploring their gut microbiome by cultivation

T. Clavel
Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH University Aachen, Germany 
03:30 pm

Interpreting gnotobiotic models: what are the missing links?

V. Arulampalam
Karolinska Institutet, Stockholm, Sweden 
04:00 pm

Development of an in vivo model to study the impact of the microbiota on sexually transmitted infection control and immune responses

C. Adapen1, MT. Nugeyre1-2, N. Tchitchek1, C. Cannou1-2, V. Contreras1, J. Ravel3, R. Le Grand1, R. Marlin1, E. Menu*1-2
1IDMIT, CEA/Université Paris Sud/INSERMU1184, Fontenay-aux-Roses, France 2Virology, Institut Pasteur, Paris, France 3Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States 
04:15 pm

Understanding the variability of the fecal microbiota to better control phenotypic variability and to prepare comprehensive Host – Microbial genetics interactions study of IMPC knock-out mice

G. Pavlovic1, L. Lindner1, Y. Herault1-2
1Institut Clinique de la Souris - ICS - CELPHEDIA - PHENOMIN, Illkirch, France 2Centre National de la Recherche Scientifique, UMR7104, Illkirch, France 
Coffee break
04:30 pm-05:00 pm
Models of pathogenesis - Part I
05:00 pm-06:30 pm
Chair: Pizarro-Cerda Javier, Paris
05:00 pm

Do pathogens hijack commensals' anaerobic pathways in Crohn's disease?

M. Leclerc
MICALIS Institute, INRA, Jouy-En-Josas, France 
05:30 pm

Role of microbiota in malnutrition and environmental enteropathy

B. Finlay
Michael Smith Laboratories, University British Columbia, Vancouver, Canada 
06:00 pm

Tryptophan metabolism and gut microbiota in health and disease

H. Sokol
Sorbonne Université, École normale supérieure, PSL Research University, CNRS, INSERM, AP-HP, Hôpital Saint-Antoine, Laboratoire de biomolécules, Paris, France 
Poster session & light bites & drinks
06:30 pm-08:00 pm
Tuesday, October 16, 2018
Raising community, Challenges to access to the models
09:00 am-01:00 pm
Chair: Macpherson Andrew J. S., Bern
09:00 am

INFRAFRONTIER – resources and services to advance the understanding of human health and disease using mammalian models

M. Hagn*, M. Hrabé De Angelis, Infrafrontier Consortium
Helmholtz Zentrum München (HMGU-IEG), Neuherberg, Germany 
09:20 am

Challenges and opportunities in metagenomic and metatranscriptomic profiling of mouse gut microbiota

M. Adams
The Jackson Laboratory, United States 
09:40 am

Harnessing the microbiome: Solutions and opportunities for mouse research models

P.E. Dubé
Applications Scientist, Taconic Biosciences, New York, United States 
10:00 am

Maintaining the Status Quo: Challenges for vendors to provide germ-free, custom flora, and static flora standard strain mice to the research community

K. Henderson
Senior Director of Laboratory Services, Charles River Laboratories, United States 
10:20 am

Microbiota approach in breeding facilities

J. Habyarimana
JANVIER LABS, Saint Berthevin Cedex, France 
10:30 am

Evolution of housing systems in Gnotobiotic research

G. Milite
Consultant in Lab. Animal Science, Udine, Italy 
10:50 am

Operational performance and selected key technical issues related to the use of sealed IVC system dedicated to gnotobiotic mouse studies

P. Hardy
Veterinary & Professional Services, ALLENTOWN INC, Bussy Saint Georges, France 
11:10 am

Gnotobiology Facility implementation, achievements, and challenges

M. Rebelo
Animal House Core Facility of Instituto Gulbenkian de Ciência, Ciência, Portugal 
11:30 am

Coffee break

11:50 am

Gnotobiotic Organizations; A mechanism to build community, past, present and future

B. Theriault
Director, Gnotobiotic Research Animal Facility, Animal Resources Center, Associate Professor, Department of Surgery, The University of Chicago, United States 
12:10 pm

Funding agencies / representative from the European Commun

D. Hadrich
European Commission, Innovative and Personalised Medicine Unit, Health Directorate, Directorate-General Research and Innovation, Brussels, Belgium 
12:30 pm

Round table discussion

01:00 pm-02:30 pm
Models of pathogenesis - Part II
02:30 pm-05:45 pm
Chair: Chevalier Grégoire, Paris
02:30 pm

Our intestinal microbiota as a source of Next-Generation Probiotics for Human and Animal Health

P. Langella*, R. Martin-Rosique, S. Miquel, C. Michon, C. Bridonneau, F. Chain, M. Thomas, J.M. Chatel, L. Bermudez, H. Sokol
Commensal and Probiotics-Host Interactions Laboratory, Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-En-Josas, France 
03:00 pm

Microbiota modulates depressive-like behavior via the endocannabinoid system

G. Chevalier
Microenvironment & Immunity Unit, Institut Pasteur, Paris, France 
03:30 pm

We are what we eat: modern stressors of the host-microbiota super-organism

B. Chassaing
Neuroscience Institute & Institute for Biomedical Sciences, Georgia State University, Atlanta, United States 
04:00 pm

Coffee break

04:30 pm

Gut microbiota in insulin resistance and type 2 diabetes

L. Manneras Holm
Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University Of Gothenburg, Sweden 
05:00 pm

The outcome of MNV-triggered IBD in mice depends on the microbiota composition

M. Basic*1, S. Bolsega1, A. Smoczek1, B. Stecher-Letsch2, A. Bleich1
1Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany 2Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University of Munich, Munich, Germany 
05:15 pm

Gut microbial metabolite induces autistic-like phenotypes in mouse

P. Bermudez1, J. Becker2, L. Martinez Gili3, A. Myridakis3, ME. Dumas3, M. Neunlist4, J. Le Merrer2, N. Glaichenhaus1, L. Davidovic*1
1IPMC, CNRS UMR7275, Valbonne, France 2INRA UMR-0085, CNRS UMR-7247, Nouzilly, France 3Imperial College, London, United Kingdom 4TENS-Inserm U1235, Nantes, France 
05:30 pm

Intestinal organoids as a tool to study microbiota-epithelium interactions

A. Levy1-2, A. Stedman1, E. Deutsch3, F. Donnadieu1, P.J. Sansonetti1-2, G. Nigro*1
1Molecular Microbial Pathogenesis Unit, INSERM U1202, Department of Cellular Biology of Infection, Institut Pasteur, Paris, France 2Chaire de Microbiologie et Maladies Infectieuses, Collège de France, Paris, France 3Department of Radiation Oncology, INSERM U1030, Gustave Roussy, Université Paris-Saclay, Villejuif, France 
Closing remarks, Poster awards
05:45 pm-06:15 pm
Gala Dinner
08:00 pm-23:30

Invited Speakers

Mark Adams, The Jackson Laboratory for Genomic Medicine, Farmington, United States
Velmurugesan Arulampalam, Karolinska Institutet, Stockholm, Sweden
Nadine Cerf-Bensussan, UMR-S1163 Institut Imagine, Paris, France
Benoît Chassaing, Universitätsklinikum Aachen, Aachen, Germany
Grégoire Chevalier, Institut Pasteur, Paris, France
Thomas Clavel, Universitätsklinikum Aachen, Aachen, Germany
Philip Dubé, Taconic Biosciences, Inc., New York, United States
Brett Finlay, University of British Columbia, Vancouver, Canada
Dirk Hadrich, European Commission, DG Research & Innovation, Brussels, Belgium
Michael Hagn, Helmholtz Zentrum München, München, Germany
Patrick Hardy, Allentown Inc, Bussy Saint Georges, France
Ken Henderson, Charles River, Wilmington, United States
Christophe Junot, CEA/Laboratoire d’Etude du Métabolisme des Médicaments, Gif-Sur-Yvette, France
Philippe Langella, MICALIS Institute, INRA, Jouy-En-Josas, France
Marion Leclerc, MICALIS Institute, INRA, Jouy-En-Josas, France
François Leulier, Institut de Génomique Fonctionnelle de Lyon (IGFL), Lyon Cedex 07, France
Jean-Pierre Levraud, Institut Pasteur, Paris, France
Andrew J. S. Macpherson, University Bern, Bern, Switzerland
Louise Manneras Holm, Sahlgrenska Universitetssjukhuset, Göteborg, Sweden
Giulia Nigro, Institut Pasteur, Paris, France
Manuel Rebelo, Instituto Gulbenkian de Ciência, Oeiras, Portugal
Harry Sokol, Saint-Antoine Hospital, Paris, France
Barbel Stecher, Ludwig-Maximilians-Universität München, München, Germany
Betty Theriault, The Microbiome Center, Chicago, United States


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